KAPA HyperCap Workflow

Evolving together with Roche Sample Prep Solutions
The answers of tomorrow, today

In translational research, the “status quo” won’t cut it.

You want to spend less time sequencing and more time discovering; we get that. Now, you can unlock the true potential of your starting material and spend more time on the work that matters most.

Discover more from every sample with our improved workflow innovation!

Lab technician looking into the distance

KAPA HyperCap Workflow takes a revolutionary approach to sample prep.

We combined all reagents and accessories required for Library Preparation and Target Enrichment in a single, automated workflow to streamline your next discovery.

  • Superior capture uniformity
  • Higher target coverage
  • Lower duplicate rate
  • Increased confidence in variant detection

Backed by the combined expertise of Roche and KAPA, you can now amplify your research with next-generation quality, fewer manual steps, and simplified ordering from a single trusted vendor.

Get the most out of your starting material

Improved Library Preparation with superior probe-design algorithm

  • Elevate conversion efficiency and decrease index misassignments with our innovative adapters and primer mix
  • Enhance sequencing performance with KAPA HyperPlus Kit, featuring end-repair and A-tailing chemistry
  • Experience a faster workflow, higher library yields, and improved library complexity with single-sided size selection after ligation

Optimized Target Enrichment with higher probe fidelity

  • Increase capture uniformity and sequencing efficiency with higher fidelity probes manufactured with KAPA HiFi polymerase
  • Benefit from confirmed presence and expected concentration of probes through our robust NGS-based QC of all KAPA Target Enrichment Probe pools
  • Improve flexibility and efficiency with capture probe reaction packs, exceeding 4,000 reactions
  • Build on the convenience of having all the accessories you need available for an all-inclusive workflow, which includes the KAPA HyperPure Beads, for highly consistent reaction purification and size selection
Lab technician looking into the distance

Execute your unique vision with the new HyperDesign Tool

Probe design is a critical first step in NGS Target Enrichment.

Ensure you get the start your research deserves. The HyperDesign Tool makes it easy to create your own custom designs, allowing you to access difficult genomic regions, and yield greater fold-enrichment of your targets.

  • Powered by Roche’s renowned probe-design algorithm
  • Simplify design with a user-friendly web interface
  • Get 24/7 access to expert designer support

Enrich your next discovery with highest-quality results and cost-saving efficiencies.

Talk to your Roche representative to update your workflow!

Lab Value

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Research Value

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See in detail how KAPA
HyperCap Workflow
can enrich your research

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Enhance your sample prep process
from DNA input to enriched library,
ready to sequence

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DNA timeline of Roche and KAPA innovation

Our proven history of innovation in sample preparation

1999 NimbleGen (NG) established based on a breakthrough technology

2007 Roche adds NG to its pioneering NGS family

2009 Release of Exome v1 & v2 for in-solution capture

2015 KAPA Biosystems’ exceptional NGS Library Prep portfolio acquired

2017 Launch of HyperCap Workflow for integrated sample prep

2018 SeqCap EZ Prime Exome launched as top-performing exome to date

2020 Launch of upgraded KAPA HyperCap Workflow

Supporting better beginnings for improved outcomes

Obtaining the most relevant information while optimizing your sequencing resources requires the best sample preparation methods.

As sequencing technologies become more accessible and affordable, Roche is here to support your ambition for finding answers.


Our continually evolving portfolio features innovative tools for a wide range of applications to consistently ensure quality and performance so you can sequence less and discover more.

Together, we can push the boundaries of clinical research.

For Research Use Only. Not for use in diagnostic procedures.

HYPERCAP, KAPA and SEQCAP are trademarks of Roche.

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©2019 F. Hoffmann-La Roche Ltd
02.01.2019